#1 19-09-2018 05:46:04

Date d'inscription: 05-11-2016
Messages: 470


WASHINGTON, Sept. 7 (Xinhua) -- An experimental therapy known as immunotherapy has shown promise in treating patients with non-Hodgkin lymphoma, a blood cancer that affects the lymph system, U.S. researchers said Wednesday.

The study, published in the U.S. journal Science Translational Medicine, involved using patients' own immune cells, which were taken out, modified and then injected back to hunt and kill cancer cells.

In the trial, 32 participants, who have previously exhausted multiple conventional cancer treatments, received an infusion of the so-called CAR T cells following chemotherapy that was given to make space in the patients' bodies for the infused cells.

The researchers found that the CAR T cells most effectively knocked out the cancer in a group of 11 patients who received a two-drug combination chemo followed by an intermediate dose of the engineered T cells.

Seven of these participants, or 64 percent, went into complete remission, they said.

Overall, among all 20 patients who received the two-drug chemo regimen, half of them achieved a complete remission.

Of the remaining 12 patients who received different chemotherapy, only one went into complete remission after CAR T-cell infusion.

The CAR T cell therapy involves modifying disease-fighting T cells extracted from patients' bloodstreams to allow them to contain a synthetic, cancer-targeting chimeric antigen receptor in their genomes.

When the modified T cells were intravenously transferred back into the patients, they can target a molecule called CD19 that is found on the surface of certain white blood cells, including some types of lymphoma cells.

There are several ongoing trials of CAR T cells in the U.S., and this study's hallmark is its use of a one-to-one ratio of helper and killer CAR T cells, which join forces to kill CD19-positive tumor cells, said Cameron Turtle, an immunotherapy researcher at Fred Hutchinson Cancer Research Center and one of the study leaders.

"The main message is that you can treat patients with non-Hodgkin's lymphoma with CAR T cells and get very good response rates with optimization of the CAR T-cell dose and lymphodepletion (chemotherapy)," said Turtle.

ISLAMABAD, Oct. 9 (Xinhua) -- Pakistan on Sunday strongly condemned terrorist attack in Turkey which killed at least 18 people, including security personnel.

Turkish officials said that a car bomb targeting a checkpoint in Semdinli district of Turkey's Hakkari province killed 10 soldiers and eight civilians and wounded a dozens of others on Sunday.

"Pakistan condemns this mindless act of terrorism in the strongest possible terms. We extend our heart-felt sympathies and condolences to the bereaved families and to the fraternal people and government of Turkey. We also pray for the speediest and fullest recovery of the wounded," the Foreign Ministry said in a statement.

The statement said the people of Pakistan stand in abiding solidarity with Turkey in the fight against terrorism.

"There is no doubt that those seeking to disturb the peace, stability and internal harmony of Turkey would never succeed. We remain firm in our belief that the brotherly people of Turkey would decisively defeat the scourge of terrorism with their unshakable resolve," the Foreign Ministry said.

The statement said Pakistan also reiterates its condemnation of terrorism in all its forms and manifestations.

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